MicrobiologybioRxiv
Acquisition of the L452R mutation in the ACE2-binding interface of Spike protein triggers recent massive expansion of SARS-Cov-2 variants
V. Tchesnokova, H. Kulakesara, L. Larson…·E. V. Sokurenko
The paper identifies the L452R mutation in the Spike protein as a key driver of recent SARS-CoV-2 variant expansion, particularly in California, and suggests its adaptive significance for viral infectivity and antibody escape.
DOI 10.1128/jcm.00921-21