DNA break clustering inside repair domains predicts cell death and mutation frequency in human fibroblasts and in Chinese hamster cells for a 10^3x range of linear energy transfers
E. Pariset, I. Plante, A. L. Ponomarev, L. Viger, T. Evain, S. R. Blattnig, S. V. Costes
This paper introduces a model to predict cell death and mutation frequency in response to cosmic radiation by simulating DNA break clustering and using experimental data from human and Chinese hamster cells.
bioRxiv · Nov 30, 2020 · PreprintCell Biology