ANGPTL8 protein-truncating variant and the risk of coronary disease, type 2 diabetes and adverse effects
Pyry Helkkula, Tuomo Kiiskinen, Aki Samuli Havulinna, Juha M Karjalainen, Seppo V. P. Koskinen, Veikko V Salomaa, FinnGen, Mark J. Daly, Aarno V. Palotie, Ida Surakka, Samuli Ripatti
The paper identifies protein-truncating variants in ANGPTL8, ANGPTL4, and LIPG associated with lipid levels and cardiometabolic disease risk, and reports their associations with type 2 diabetes, coronary artery disease, and other adverse effects.
PLoS Genetics · Apr 28, 2021Peer-reviewedGenetic & Genomic Medicine