BitBIRCH-Lean: chemical space in the palm of your workstation
Ignacio Pickering, Krisztina Zsigmond, Kenneth López Pérez, Miroslav Lžičař, Ramón Alain Miranda‐Quintana
BitBIRCH-Lean efficiently clusters large molecular libraries on workstations, achieving 2X speedup over the original BitBIRCH with no loss in cluster quality.
bioRxiv · Oct 22, 2025 · PreprintBioinformatics