Ancestral sequence reconstruction using generative models
Edo Dotan, Elya Wygoda, Asaf Schers, Iris Lyubman, Yonatan Belinkov, Tal Pupko
This paper introduces BetaReconstruct, a generative model for ancestral sequence reconstruction that outperforms traditional methods without requiring multiple sequence alignments or phylogenetic trees.
bioRxiv · Jan 21, 2026 · PreprintBioinformatics