SNV and indel error modeling of deep targeted cell-free DNA sequencing data for sensitive detection of circulating tumor DNA in colorectal cancer
Mathilde Hartvig Diekema, Mads Heilskov Rasmussen, Simon Opstrup Drue, Amanda Frydendahl, Claus L. Andersen, J Engholm Pedersen
PyDREAMS improves detection of low-frequency ctDNA by modeling SNV and indel errors in cfDNA sequencing data from colorectal cancer patients.
bioRxiv · Jun 2, 2026 · PreprintBioinformatics