Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microglia
Brooke A. Lester, Colin Kelly, Sara N. Henry, Isaac P. Elias, Sophia E. Cevenini, Margaret R. Hendrickson, Taeseo Park, Theodore D. Ashley, Julianna M. Beltz, J Milner, Alicia M. Pickrell, Paul D. Morton
This study examines how germ-free conditions affect microglial dynamics in piglets' prefrontal cortex, finding region-specific neuroinflammatory changes in the absence of microbial colonization.
bioRxiv · Mar 24, 2026 · PreprintNeuroscience