Author

J. C. Moravec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Approach:Bayesian inference· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

A. Gavryushkin· 2 shared A. J. Drummond· 1 shared D. Spector· 1 shared D. Welch· 1 shared K. Chen· 1 shared R. Lanfear· 1 shared S. Diermeier· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

A. Gavryushkin

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2 papers

Recent·Most cited

Testing for phylogenetic signal in single-cell RNA-seq data

J. C. Moravec, R. Lanfear, D. Spector, S. Diermeier, A. Gavryushkin

This study shows that scRNA-seq data can be used for phylogenetic analysis, revealing tumor clonal composition through expression levels and SNVs.

Journal of Computational Biology · Apr 18, 2023Peer-reviewedCancer Biology

Accounting for errors in data improves timing in single-cell cancer evolution

K. Chen, J. C. Moravec, A. Gavryushkin, D. Welch, A. J. Drummond

This study improves timing accuracy in single-cell cancer evolution by modeling errors in single-cell DNA sequencing data using BEAST2, showing that error accounting shifts divergence times forward and reduces overestimation of phylogenetic diversity.

bioRxiv · Mar 17, 2021 · PreprintEvolutionary Biology