Trade-Offs between Speed, Accuracy, and Dissipation in tRNAIle Aminoacylation
Q. Yu, J. D. Mallory, A. Kolomeisky, J. Ling, O. A. Igoshin
This study uses a stochastic model to analyze how tRNAIle aminoacylation balances speed, accuracy, and energy dissipation in E. coli, revealing an economic proofreading strategy that optimizes performance under tolerable error rates.
The Journal of Physical Chemistry Letters · Apr 30, 2020Peer-reviewedBiophysics