J. Echave

Evolutionary coupling range varies widely among enzymes depending on selection pressure

The paper shows that evolutionary coupling range in enzymes varies with selection pressure, not physical coupling, from 2 to 20 angstroms.

Fast and exact single and double mutation-response scanning of proteins

This paper introduces analytical methods for fast and exact calculation of mutation-response matrices in proteins, outperforming simulation-based approaches.

Beyond stability constraints: a biophysical model of enzyme evolution with selection for stability and activity

This paper introduces a biophysical model of enzyme evolution that incorporates selection for both stability and activity, showing it better fits observed evolutionary rates than a stability-only model.