Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B
F. Orädd, J. H. Steffen, P. Gourdon, M. Andersson
This study uses molecular dynamics simulations to show that copper binding increases dynamics in the N-terminal regulatory domain of ATP7B by altering interactions between metal-binding domains and the core protein.
bioRxiv · Apr 5, 2022Biophysics