RNA-binding proteins with mixed charge domains self-assemble and aggregate in Alzheimer’s Disease
I. Bishof, E. B. Dammer, D. M. Duong, M. Gearing, J. J. Lah, A. I. Levey, N. T. Seyfried
This study identifies mixed charge domains in RNA-binding proteins that self-assemble and aggregate in Alzheimer’s Disease, linking them to Tau co-aggregation and nuclear RNA granule formation.
bioRxiv · Jan 4, 2018Biochemistry