Critical re-evaluation of the slope factor of the operational model of agonism: Do not exponentiate operational efficacy
The paper re-evaluates the slope factor in the operational model of agonism, showing that using the Hill coefficient provides more accurate estimates of agonist efficacy and affinity than the Black & Leff slope factor.
bioRxiv · Apr 7, 2021 · PreprintPharmacology & Toxicology