Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function
H. Gokcan, J. K. Bedoyan, O. Isayev
This study uses molecular dynamics simulations to analyze the structural and functional impact of pathogenic E1α variants on the pyruvate dehydrogenase complex-E1, revealing allosteric effects and potential therapeutic targets.
bioRxiv · May 17, 2022Biochemistry