Structure-enabled enzyme function prediction unveils elusive terpenoid biosynthesis in archaea
R. Samusevich, S. M. Akmese, T. Hebra, R. Bushuiev, M. Engst, J. Kulhanek, A. Bushuiev, J. D. Smith, T. Calounova, H. Smrckova, M. Molineris, R. Schwartz, A. Svoboda, R. Chatpatanasiri, S. C. Kampranis, , T. Pluskal
The paper introduces EnzymeExplorer, a machine-learning pipeline that predicts enzyme function, discovering new terpenoid synthases in archaea and expanding their known taxonomic distribution.
bioRxiv · Jan 29, 2024 · PreprintBiochemistry