Author

J. M. Schmiedel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Organism:human· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Faure· 2 shared B. Lehner· 2 shared A. Marti-Aranda· 1 shared C. Hidalgo· 1 shared C. Hidalgo-Carcedo· 1 shared G. Diss· 1 shared J. Domingo· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

A. J. Faure

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2 papers

Recent·Most cited

The genetic architecture of protein stability

A. J. Faure, A. Marti-Aranda, C. Hidalgo, J. M. Schmiedel, B. Lehner

This study shows that the genetic architecture of some proteins is simple, allowing accurate prediction using interpretable biophysical models despite the complexity of deep neural networks.

bioRxiv · Oct 27, 2023Biophysics

Global mapping of the energetic and allosteric landscapes of protein binding domains

A. J. Faure, J. Domingo, J. M. Schmiedel, C. Hidalgo-Carcedo, G. Diss, B. Lehner

The paper develops a method using deep mutational scanning to map allosteric landscapes of protein domains, revealing widespread allosteric mutations and their effects on binding affinity.

bioRxiv · Sep 14, 2021 · PreprintBiophysics