A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage gated sodium channels
Y. Lin, E. Tao, J. P. Champion, B. Corry
This paper uses multiscale simulations to show that PI(4,5)P2 binds to Nav channels, modulating their activity by affecting conformational changes and recovery from inactivation.
bioRxiv · Jul 16, 2023 · PreprintBiophysics