The interplay between molten globules and heme disassociation defines human hemoglobin disassembly
P. P. Samuel, M. A. White, W. C. Ou, D. A. Case, G. N. Phillips, J. S. Olson
This paper develops a quantitative model of human hemoglobin disassembly, showing that heme dissociation and molten globule intermediates drive structural changes, leading to pathophysiological outcomes like Heinz bodies and hemolysis.
Biophysical Journal · Mar 1, 2020Peer-reviewedBiophysics