Understanding flux switching in metabolic networks through an analysis of synthetic lethals
Sowmya Manojna Narasimha, Tanisha Malpani, Omkar S. Mohite, J. Saketha Nath, Karthik Raman
The paper identifies alternate metabolic pathways rerouted during synthetic lethal reaction pairs using a constraint-based optimization approach and applies it to genome-scale models.
npj Systems Biology and Applications · Sep 17, 2024Peer-reviewedSystems Biology