Author

J. Shearer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:E. coli· 1 Approach:simulation· 1 Assay:structural biology· 1

Frequent Co-Authors

S. Khalid· 3 shared A. J. lloyd· 1 shared A. York· 1 shared C. Dowson· 1 shared C. I. del Genio· 1 shared D. Jefferies· 1 shared D. Roper· 1 shared J. K. Marzinek· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiophysics

S. Khalid

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Author profile →

3 papers

Recent·Most cited

Structure-based modelling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant that functions at the cytoplasmic membrane interface

A. York, A. J. lloyd, C. I. del Genio, J. Shearer, K. Hinxman, K. Fritz, V. Fulop, S. Khalid, C. Dowson, D. Roper

The paper models MurM's structure and dynamics to show its interaction with phospholipids and Lipid II, revealing its role in penicillin resistance in Streptococcus pneumoniae.

bioRxiv · Jun 18, 2020Biochemistry

Molecular Dynamics Simulations of Bacterial Outer Membrane Lipid Extraction: Adequate Sampling?

J. Shearer, J. K. Marzinek, P. J. Bond, S. Khalid

This study evaluates simulation protocols for accurately sampling lipopolysaccharide dynamics in bacterial membranes, finding that decoupling cations improves convergence while lateral mixing remains slow.

bioRxiv · Jun 11, 2020Biophysics

The outer membrane proteins OmpA, FhuA, OmpF, EstA, BtuB and OmpX have unique lipopolysaccharide fingerprints.

J. Shearer, D. Jefferies, S. Khalid

The paper uses molecular dynamics simulations to show that six E. coli outer membrane proteins have unique interactions with lipopolysaccharide, influenced by membrane composition and lipid mobility.

bioRxiv · Oct 19, 2018Biophysics