Author

Jack Simons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex Hawkins‐HookeriD· 1 shared Jakub Kmec· 1 shared Oliver Bent· 1 shared Paul DuckworthiD· 1 shared Shikha Surana· 1 shared

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2024-2024 · peak 1/yr

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1 shared paperBioinformatics

Alex Hawkins‐HookerORCID

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1 paper

Recent·Most cited

Likelihood-based fine-tuning of protein language models for few-shot fitness prediction and design

Alex Hawkins‐Hooker, Shikha Surana, Jack Simons, Jakub Kmec, Oliver Bent, Paul Duckworth

This paper compares likelihood-based and embedding-based methods for fitness prediction and design using protein language models, finding likelihood-based fine-tuning consistently outperforms embedding-based approaches.

bioRxiv · May 28, 2024 · PreprintBioinformatics