Persistent CD4+ T cell functional deficits during recovery from prolonged symptomatic SARS-CoV-2 infection
Jadith Ziegler, Christina Lawrence, Seán Turner, Nathan P. Pezant, Nancy Redinger, Carla J. Guthridge, Kenneth Smith, Jingrong Chen, Joel M. Guthridge, Judith A. James, Susannah Rankin, Linda F. Thompson, Amy Darise Farris, Susan Kovats
This study identifies persistent CD4+ T cell functional deficits in individuals with prolonged SARS-CoV-2 symptoms, characterized by low CD4 expression and impaired activation responses.
bioRxiv · Dec 4, 2025 · PreprintImmunology