Computational Redesign of an Antifreeze Protein Using Deep Learning
Cianna N. Calia, Arthur J. Altunc, Rosemary J. Eufemio, Benjamin O. Alvarado, Jake D. Huynh, Eunkeu Oh, Michael D. Burkart, Konrad Meister, Francesco Paesani
This study uses deep learning to redesign an antifreeze protein, identifying variants with improved properties but not surpassing wild-type activity.
bioRxiv · Jun 24, 2026 · PreprintBiophysics