Single-cell foundation models reveal context-sensitive cancer programmes under subtype shift
James Wallace, Gehad Youssef, Namshik Han
The paper fine-tunes two scFMs on cancer subtypes and shows they outperform LightGBM on out-of-domain subtypes, with context-sensitive adaptation supported by interpretability analysis.
bioRxiv · May 1, 2026 · PreprintBioinformatics