Topographical archetypes of somatic mutagenesis in cancer
Allen W. Lynch, S W Lee, Jan P. Hummel, Benedikt Geiger, Michael S. Lawrence, Hu Jin, D. Gulhan, Peter J. Park
The paper introduces MuTopia, a framework that identifies topographic archetypes of mutagenesis in cancer genomes, revealing that mutational processes are constrained by replication timing and chromatin state.
bioRxiv · Apr 21, 2026 · PreprintBioinformatics