Epistatic Features and Machine Learning Improve Alzheimer's Risk Prediction Over Polygenic Risk Scores
Stephen Hermes, Janet Cady, Steven L. Armentrout, James O’Connor, Sarah E. Carlson, Carlos Cruchaga, Thomas S. Wingo, Ellen McRae Greytak, The Alzheimer’s Disease Neuroimaging Initiative
This study develops a paragenic risk score that improves Alzheimer's disease risk prediction by incorporating epistatic interactions and machine learning, outperforming traditional polygenic risk scores.
medRxiv · Feb 10, 2023 · PreprintGenetic & Genomic Medicine