Generalist large language models complement tailor-made predictors for tumor genomics interpretation
Jennifer Yu, Madison Darmofal, Michele Waters, January Choy, Thinh N. Tran, Chenlian Fu, Leah Morales, U Kaicheng, Ross L. Levine, Nikolaus Schultz, Michael F. Berger, Quaid Morris, Justin Jee
This paper evaluates generalist large language models (LLMs) in tumor genomic interpretation tasks, finding they can complement or outperform task-specific models in some cases.
bioRxiv · May 22, 2026 · PreprintGenomics