Cryoelectron tomography of HIV-1 cell-cell transmission conjugates reveals a secluded environment for viral assembly and transfer
Jacob Jensen, Marcela Sabino Cunha, Broti Adhikary, Zaida K. Rodriguez, Iszavier Moe, Jasmine Beldin, Dmitry Lyumkis, Luiza Mendonça
This study uses cryoET to reveal that HIV-1 cell-cell transmission occurs in secluded intercellular spaces, and develops flow cytometry to show CD4 partially mediates conjugate formation but not entry.
bioRxiv · Jun 12, 2026 · PreprintMicrobiology