A Common Pathogenic Founder Variant in Rwandan Breast Cancer Cases
Achille Van Christ Manirakiza, Shakuntala Baichoo, Annette Uwineza, Damas Dukundane, Eulade Rugengamanzi, Janvière Mutamuliza, Allison Niragira, Raissa Muvunyi, Jeffrey Besada, Sarah M. Nielsen, Brianna A. Bucknor, Diane Renee Koeller, Caroline V. Andrews, Léon Mutesa, Temidayo A. Fadelu, Timothy Richard Rebbeck
The paper identifies a common BRCA1 founder variant in Rwandan breast cancer patients and estimates its origin to be around 4,000-10,000 years ago.
bioRxiv · May 29, 2026 · PreprintGenetics