Time-resolved dual RNA-Seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection
Rieza Aprianto, Jelle Slager, Siger Holsappel, Jan-Willem Veening
This study uses time-resolved dual RNA-Seq to analyze host and pneumococcal transcriptomes during early infection, revealing activation of the epithelial glutathione-detoxification pathway and repression of innate immune responses by adherent bacteria.
Genome Biology · Sep 27, 2016Peer-reviewedMicrobiology