Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases
Elle M. Weeks, Jacob C. Ulirsch, Nathan Cheng, Brian L. Trippe, Rebecca S. Fine, Jenkai Miao, Tejal A. Patwardhan, Masahiro Kanai, Joseph Nasser, Charles P. Fulco, Katherine C. Tashman, François Aguet, Taibo Li, José Ordovás-Montañés, Christopher S. Smillie, , Hilary K. Finucane
The paper introduces a method to prioritize causal genes for complex traits by integrating GWAS data with gene expression and biological data, achieving high precision in gene-trait pair identification.
Nature Genetics · Jul 13, 2023Peer-reviewedGenetic & Genomic Medicine