Onset of Mismatch Repair by the Human Mismatch Repair Protein, MutSbeta for a Biosensing Device
Jack Devlin, Jenna Madigan, Isaac Macwan
The paper uses molecular dynamics simulations to study how MutSbeta interacts with mismatched DNA, showing its stabilization and scanning initiation after ~75ns, and validates these findings for a biosensing application.
bioRxiv · Jan 31, 2024 · PreprintBiophysics