Perdurant TTC21B protein in the early mouse embryo is required for proper forebrain neural progenitor proliferation.
Rebekah Niewoehner, David Paulding, Jesus Leal, Rolf W. Stottmann
This study shows that Ttc21b is essential for forebrain neural progenitor proliferation and differentiation in mice, leading to microcephaly due to disrupted cell cycle and cytoskeletal defects.
bioRxiv · Jan 14, 2025 · PreprintDevelopmental Biology