Prenatal stress increases corticosterone levels in offspring by impairing placental glucocorticoid barrier function
Can Liu, Hongya Liu, Hongyu Li, Deguang Yang, Ye Li, Rui Wang, Jiashu Zhu, Shuqin Ma, Suzhen Guan
This study shows prenatal stress impairs the placental glucocorticoid barrier by altering DNA methylation of key genes, leading to increased corticosterone levels in offspring.
PLoS ONE · Jul 18, 2025Peer-reviewedDevelopmental Biology