Metformin increases tauroursodeoxycholic acid levels to improve insulin resistance in diet-induced obese mice
Ya Zhang, Cheng Yang, Jian Liu, Dan He, Jihui Zuo, Liping Yan, Ronald Wallen Thring, Mingjiang Wu, Yitian Gao, Haibin Tong
This study shows metformin improves insulin resistance in obese mice by increasing tauroursodeoxycholic acid (TUDCA), which reduces oxidative stress and enhances insulin signaling through the Nrf2/ARE pathway.
bioRxiv · May 26, 2020 · PreprintMolecular Biology