Multiomics Analysis Reveals Extensive Remodeling of the Extracellular Matrix and Cellular Metabolism Due to Plakophilin-2 Knockdown in Guinea Pigs
Rui Song, Haiyan Wu, Lihui Yu, Jingning Yu, WenHui Yang, Wenjun Wu, Fei Sun, Haizhen Wang
This study investigates the molecular and metabolic effects of PKP2 knockdown in a guinea pig ARVC model, revealing ECM remodeling and metabolic changes associated with the disease.
bioRxiv · Mar 11, 2024 · PreprintGenetics