Clonal Hematopoiesis Mutations Increase Risk of Alzheimer's Disease with APOE ϵ3/ϵ3 Genotype
Jaejoon Choi, Kyung Park, Yann Le Guen, Jong-Ho Park, Zinan Zhou, Liz Enyenihi, Ila Rosen, Yoon-Ho Choi, Christopher A. Walsh, Jong-Won Kim, August Yue Huang, Eunjung Alice Lee
This study finds that Alzheimer's disease patients have more clonal hematopoiesis mutations than controls, especially those with APOE ε3/ε3 genotype, suggesting a risk factor independent of APOE ε4.
bioRxiv · May 19, 2025 · PreprintGenetics