A comparison of scalable approaches for the pairwise analysis of large pathogen genomic and spatial datasets: an application to studying Mycobacterium tuberculosis transmission
Yu Lan, Chieh-Yin Wu, H Y Lin, Ted Cohen, Joshua L. Warren
The paper compares case-control and divide-and-conquer methods for efficient pairwise analysis of large pathogen genomic and spatial datasets, finding the case-control approach more robust for estimating transmission associations.
bioRxiv · May 21, 2026 · PreprintMicrobiology