Author

Jouke J. Hottenga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:eQTL / molecular QTL mapping· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

André G. Uitterlinden· 3 shared Albert HofmaniD· 2 shared Alexandra ZhernakovaiD· 2 shared Carla J.H. van der Kallen· 2 shared Coen D.A. StehouweriD· 2 shared Daria Zhernakova· 2 shared Diana van HeemstiD· 2 shared Dorret I. Boomsma· 2 shared

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2016-2017 · peak 3/yr

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10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

André G. Uitterlinden

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4 papers

Recent·Most cited

Disease variants alter transcription factor levels and methylation of their binding sites

Marc Jan Bonder, René Luijk, Daria Zhernakova, Matthijs Moed, Patrick Deelen, Martijn Vermaat, Maarten van Iterson, Freerk van Dijk, Michiel van Galen, Jan Bot, Roderick C. Slieker, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, , C

The paper identifies trans-meQTLs linking disease variants to methylation changes at transcription factor binding sites, revealing eight-fold more downstream effects than trans-eQTLs.

Nature Genetics · Jan 1, 2017Peer-reviewedGenomics

Hypothesis-free identification of modulators of genetic risk factors

Daria Zhernakova, Patrick Deelen, Martijn Vermaat, Maarten van Iterson, Michiel van Galen, Wibowo Arindrarto, Peter van t Hof, Hailiang Mei, Freerk van Dijk, Harm-Jan Westra, Marc Jan Bonder, Jeroen van Rooij, Marijn Verkerk, P. Mila Jhamai, Matthijs Moed, , Dorret

The paper identifies context-dependent eQTLs in peripheral blood RNA-seq data from Dutch individuals using a hypothesis-free approach, revealing gene expression influenced by cell type and signaling pathways.

Nature Genetics · Dec 5, 2016Peer-reviewedGenetics

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman, Hilary Finucane, Patrick Sulem, Katherine S. Ruth, Sean Whalen, Abhishek K. Sarkar, Eva Albrecht, Elisabeth Altmaier, Marzyeh Amini, Caterina M. Barbieri, Thibaud Boutin, Archie Campbell, , John R.B Perry

This study identifies 389 genetic signals for age at menarche and finds BMI-independent causal links between puberty timing and cancer risks.

bioRxiv · Sep 23, 2016 · PreprintGenomics

Genetic overlap between schizophrenia and developmental psychopathology: a longitudinal approach applied to common childhood disorders between age 7 and 15 years

Michel G. Nivard, Suzanne H. Gage, Jouke J. Hottenga, Catherina E.M. van Beijsterveldt, Abdel Abdellaoui, Bart M.L. Baselmans, Lannie Ligthart, Beate St Pourcain, Dorret I. Boomsma, Marcus M. Munafoò, Christel M. Middeldorp

This study examines the genetic overlap between schizophrenia and childhood psychiatric disorders using longitudinal data from two cohorts, finding stronger genetic associations with ADHD and ODD/CD as age increases.

bioRxiv · May 11, 2016 · PreprintGenetics