CH···O Interactions Are Not the Cause of Trends in Reactivity and Secondary Kinetic Isotope Effects for Enzymatic SN2 Methyl Transfer Reactions
Jianyu Zhang, Judith P. Klinman
The paper evaluates the role of CH···O interactions versus reaction compaction in enzymatic SN2 methyl transfer reactions, finding that CH···O interactions have limited impact on reaction rates and secondary KIEs.
bioRxiv · Sep 1, 2016 · PreprintBiochemistry