OGUs enable effective, phylogeny-aware analysis of even shallow metagenome community structures
Qiyun Zhu, Shi Wei Huang, Antonio Gonzalez, Imran McGrath, Daniel T. McDonald, Niina Haiminen, George Armstrong, Yoshiki Vázquez‐Baeza, Julian Yu, Justin Kuczynski, Gregory D. Sepich‐Poore, Austin D.-E. Swafford, Promi Das, Justin P. Shaffer, Franck Lejzerowicz, , Rob D. Knight
This paper introduces OGUs, a metagenome analysis method that uses sequence alignment hits to reference genomes for community analysis, showing better performance in predicting biological traits than taxonomic or 16S rRNA methods.
bioRxiv · Apr 4, 2021 · PreprintBioinformatics