Amyloid Accelerator Polyphosphate Implicated as the Mystery Density in α-Synuclein Fibrils
Philipp Huettemann, Pavithra Mahadevan, Justine Lempart, Eric Tse, Budheswar Dehury, Brian F. P. Edwards, Daniel R. Southworth, Bikash Ranjan Sahoo, Ursula Jakob
This study identifies polyphosphate as the 'mystery density' in α-synuclein fibrils by showing it binds to lysine residues, affecting fibril formation and toxicity.
PLoS Biology · Oct 31, 2024Peer-reviewedBiophysics