Application of an ecology-based analytic approach to discriminate signal and noise in low-biomass microbiome studies: whole lung tissue is the preferred sampling method for amplicon-based characterization of murine lung microbiota
J. M. Baker, K. J. Hinkle, R. A. McDonald, N. R. Falkowski, G. B. Huffnagle, R. P. Dickson
This study applies an ecology-based approach to identify signal from noise in low-biomass microbiome studies and finds whole lung tissue is better than BAL fluid for characterizing murine lung microbiota.
bioRxiv · Sep 8, 2020Microbiology