Cancer BiologybioRxiv
Expressed barcodes enable clonal characterization of chemotherapeutic responses in chronic lymphocytic leukemia
A. Al'Khafaji, C. Gutierrez, E. Brenner…·C. J. Wu
This paper develops a method to study clonal responses to chemotherapy in CLL by combining barcoding with single-cell RNA sequencing, revealing that rare drug-tolerant clones dominate post-treatment populations.