Author

D. Neuberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. J. Wu· 2 shared A. Al'Khafaji· 1 shared A. Brock· 1 shared A. C. Anderson· 1 shared A. G. Schmidt· 1 shared A. Gautam· 1 shared A. Gnirke· 1 shared A. Griffths· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCancer Biology

C. J. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

P. Tong, A. Gautam, I. Windsor, M. Travers, Y. Chen, N. Garcia, N. Whiteman, L. McKay, F. J. N. Lelis, S. Habibi, Y. Cai, L. J. Rennick, W. P. Duprex, K. McCarthy, C. L. Lavine, , D. R. Wesemann

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

bioRxiv · Mar 10, 2021Immunology

Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to graft-versus-leukemia

P. Bachireddy, C. Ennis, V. Nguyen, K. Clement, S. H. Gohil, S. A. Shukla, J. Forman, N. Barkas, S. Freeman, N. Bavli, L. Elagina, I. Leshchiner, A. W. Mohammad, L. Z. Rassenti, T. J. Kipps, , C. J. Wu

The paper investigates the evolutionary trajectories of chronic lymphocytic leukemia cells during resistance to graft-versus-leukemia, finding distinct genetic and epigenetic dynamics post-transplant compared to chemotherapy.

bioRxiv · Apr 9, 2020Cancer Biology

An endogenous glucocorticoid-cytokine signaling circuit promotes CD8+ T cell dysfunction in the tumor microenvironment

N. Acharya, A. Madi, H. Zhang, M. Klapholz, E. Christian, K. O. Dixon, G. Fell, K. Tooley, D. Mangani, J. Xia, M. Singer, D. Neuberg, O. Rozenblatt-Rosen, A. Regev, V. K. Kuchroo, A. C. Anderson

This study identifies a glucocorticoid-cytokine signaling circuit in the tumor microenvironment that promotes CD8+ T cell dysfunction and correlates with poor response to checkpoint blockade in melanoma.

bioRxiv · Oct 10, 2019 · PreprintImmunology

Expressed barcodes enable clonal characterization of chemotherapeutic responses in chronic lymphocytic leukemia

A. Al'Khafaji, C. Gutierrez, E. Brenner, R. Durrett, K. E. Johnson, W. Zhang, S. Li, K. J. Livak, D. Neuberg, A. Brock, C. J. Wu

This paper develops a method to study clonal responses to chemotherapy in CLL by combining barcoding with single-cell RNA sequencing, revealing that rare drug-tolerant clones dominate post-treatment populations.

bioRxiv · Sep 8, 2019Cancer Biology

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

L. Hinze, M. Pfirrmann, S. Karim, J. Degar, C. McGuckin, D. Vinjamur, J. Sacher, K. Stevenson, D. Neuberg, D. Bauer, F. Wagner, K. Stegmaier, A. Gutierrez

This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.

bioRxiv · Sep 12, 2018Cancer Biology