BiochemistrybioRxivPreprint
Molecular architecture of a membrane-spanning hormone acyltransferase required for metabolic regulation
M. B. Campana, F. J. Irudayanathan, T. R. Davis…·J. L. Hougland
The paper presents a structural model of GOAT, an MBOAT enzyme, using co-evolutionary constraints and computational modeling validated by biochemistry, revealing a novel acylation mechanism within a transmembrane channel.
DOI 10.1101/556233