Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia
Z. Michel, L. N. Raborn, T. Spencer, K. S. Pan, D. Martin, K. L. Roszko, Y. Wang, P. Robey, A. Boyce, M. T. Collins, L. F. de Castro
This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.
bioRxiv · Feb 23, 2024Pathology