Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
Sophie G. Kellaway, Peter Keane, Benjamin Edginton‐White, Kakkad Regha, Ella Kennett, Constanze Bonifer
The paper shows that different RUNX1 mutations alter gene regulatory networks and chromatin programming, leading to distinct hematopoietic differentiation trajectories and disease phenotypes.
Life Science Alliance · Jan 4, 2021Peer-reviewedGenomics