Conserved water molecules as structural ligands modulating pathogenic variation in human protein binding sites
Janez Konc, Karmen Recer, Tanja Kunej, Dušanka Janežič
The paper shows that conserved water molecules in protein structures are linked to pathogenic SNPs, particularly in ligand-binding regions, and demonstrates their role in disease mechanisms through molecular dynamics simulations.
bioRxiv · Apr 3, 2026 · PreprintBioinformatics