Functional normalization of 450k methylation array data improves replication in large cancer studies
Jean-Philippe Fortin, Aurelie Labbe, Mathieu Lemire, Brent W. Zanke, Thomas J. Hudson, Elana J. Fertig, Celia M.T. Greenwood, Kasper D. Hansen
The paper introduces functional normalization for 450k methylation array data, improving replication in cancer studies by reducing technical variation and batch effects.
bioRxiv · Feb 23, 2014Bioinformatics